Amazon is laying off 299 employees at multiple locations across Manhattan as the company begins its global staff reduction process.

Most of the employees affected, a total of 243 people, are listed as located at 1440 Broadway, according to a Worker Adjustment and Retraining Notification the Seattle-based giant filed with the New York Department of Labor on Monday.

Amazon calls its 1440 Broadway office its JFK25 facility — many of its NYC facilities, from offices to distribution centers, carry a similar moniker — but little is publicly available about its space there.

CIM Group bought the 25-story building for $520M in 2017, and its website says it has 250K SF of availability. WeWork has a 13-floor, 236K SF location in the building. A CIM spokesperson didn't immediately respond to a request for comment.

Amazon is laying off another 38 workers at 7 West 34th St., per the notice, where Amazon leased 417K SF from Vornado in 2014 for 17 years. Nine employees were laid off from Brookfield’s 450 West 33rd St., known as 5 Manhattan West, where Amazon took a 15-year lease for 360K SF in 2017. Five employees were laid off from 410 10th Ave., where Amazon is the anchor tenant at the 601W Cos.-owned property.

At 1350 Sixth Ave., two employees are affected, with one employee laid off at 37 East 18th St. Another employee was affected at 950 Sixth Ave.

The employee separations are set for April 18, per the notice. A representative from Amazon declined to comment beyond the detail in the filing and noted the role eliminations are related to ​​Amazon CEO Andy Jassy’s announcements this month on the company’s plans for the workforce in 2023.

Amazon is planning to lay off a total of 18,000 people, with most of the headcount cuts coming from its consumer retail business and human resources. The layoffs represent 1% of Amazon’s global workforce, which consists of some 350,000 corporate employees. However, the announcement marked the single largest mass layoff announcement since tech companies began with headcount reductions last year, Bloomberg reported.

Amazon closed dozens of logistics centers through 2022 following massive warehouse expansion through the pandemic.